Sunday, June 30, 2013

Primary Glomerularnephritis

Manifestations:
Primary Glomerularnephritis is a group of renal glomerular disease, the clinical manifestations of which are proteinuria, hematuria, edema, high blood pressure, and so on. Different patients have different degree of manifestations. For most of them, edema or swelling is their first symptom. Early in the morning, slight patients can find moderate swelling in the eyelids and face. In the afternoon, there is slight edema in lower limbs. After a short time rest, the edema can disappear. For some of them, increased blood pressure is the first symptom and then they are diagnosed with chronic Primary Glomerularnephritis. If not controlled well, Primary Glomerularnephritis may develop into renal insufficiency and even renal failure. Patients will have anemia, heart failure, and so on, which is mainly due to the damaged renal parenchyma, thus causing decreased production of red blood cells and malnutrition.
The types:
In clinic, Primary Glomerularnephritis can be divided into four kinds: acute renal glomerular nephritis, progressive renal glomerular nephritis, chronic nephritis, and latent renal glomerular nephritis. According to pathological damage, it can also be divided into the following three type, the classification of which is more common and acceptable in clinic.
1. MsPGN, the full name of which is mesangial proliferative glomerulonephtitis. It is found in youngsters in most of time, and men are more than in women. The clinical manifestations of which are continuous microscopic hematuria, recurrent hematuria, and the disease usually lasts for a long time. About half of them have been infected before. 70% of them have gross hematuria. With the disease developing, high blood pressure and renal failure will appear.
2. Chronic diffuse renal glomerulonephtitis or focal segmental renal glomerulonephtitis, which is from acute renal glomerulonephtitis that can not recover for a long time.
3. Membranous Glomerulonephritis, 80% of which show symptoms of nephrotic syndrome. Nephrotic Syndrome refers to a group of renal glomerular disease. When the protein in urine is more than 3.5g/24h and the symptoms of hypoproteinemia occur, you can be diagnosed as Nephrotic Syndrome. Other common symptoms also include severe edema and hyperlipemia. Some also show symptoms of chronic nephritis.

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