Diabetes and Stage 3 Chronic Kidney Disease

Each kidney is made of hundreds of thousands of small units called nephrons. These structures filter your blood and help remove wastes from your body. In people with diabetes, the nephrons thicken and slowly become scarred over time. The kidneys begin to leak and protein (albumin) passes into the urine. When the GFR declines to 30~59 ml/min (serum creatinine is 186-442umol/l), it indicates that diabetes has developed into diabetic kidney disease stage 3. It is a critical stage and patients should seize the time to treat. If the treatment is effective, the condition can be reversed.
How diabetes develops into stage 3 chronic kidney disease?
The exact cause is unknown. Poor control of blood sugar is thought to lead to kidney damage. If you also have high blood pressure, kidney damage is even more likely.
In some cases, family history may also play a role. Not everyone with diabetes develops this kidney problem.
People with diabetes who smoke, and those with type 1 diabetes that started before age 20 have a higher risk for kidney problems.
Symptoms of diabetic kidney disease stage 3 are as follows:
Often, there are no symptoms as the kidney damage starts and slowly gets worse. Kidney damage can begin 5 to 10 years before symptoms start.
People who have more severe kidney disease may have a poor appetite, feel tired most of the time, and have a general ill feeling.
Headache, nausea and vomiting,swelling of the legs, and many other symptoms may also occur.
Treatment for diabetic kidney disease stage 3
Stem cell therapy is considered to be the most advanced one to treat diabetes. For type 1 diabetes, stem cell can differentiate into beta cell, so the insulin can secrete normally and patients can avoid injecting insulin and take in medicine which can lower blood sugar. For type 2 diabetes, stem cell can also repair the damaged beta cells. In addition, once diabetic kidney disease develops into stage 3, there must be damaged and necrotic cells in the kidney. Stem cell can not only repair the damaged cells but also differentiate into the necrotic cells, thus rebuilding renal function.
In addition, stem cells can also enhance the immunity. Diabetes is a kind of immune disorder. So after immune is regulated, stage 3 diabetic kidney disease can not only be controlled but also will not turn worse.