When Will Creatinine Impact Renal Function

What is creatinine? It is the product from muscle’s metabolism which occurs in human body. 20g muscle can produce 1mg creatinine. It is excreted via the glomerular filtration. Creatinine can be divided into exogenous one and endogenous one . The exogenous creatinine is the outcome from the metabolism of meat food in the human body while the endogenous creatinine is the result due to the metabolism of muscle tissue in the human body. When the intake of the meat food keeps in a steady condition, and the muscle’s metabolism doesn’t change a lot, the creatinine will stay constant. The variation of density from serum creatinine is up to the filtration
of glomerulus. If the above-mentioned ability decline, the density of creatinine will go up.
Serum creatinine in the normal body represents 44—133μmoI/L. The normal range can make a difference as a result of the inspection method adopted by the laboratories in local hospitals. The normal inspection index of serum (or plasma) creatinine shows : 53—106μmoI/L for males and 44—97μmoI/L for females. The detection of serum creatinine is clinically used to judge the renal function. The kidneys are well capable of storing and compensating. The serum creatinine will increase obviously only in the case that the amount of filtration decreases to less than 1/3 of the normal one.
The patients with chronic renal failure can judge the level based on the index from the detection of serum creatinine and other related standards:
The phenomenon that the amount of serum creatinine doesn’t rise shows that the kidneys are under compensation.
The fact that the serum creatinine is more than 176.8μmoI/L indicates that the patient is suffering from renal failure. If the density of the creatinine is over 200 μmo/L, the
sufferer is likely to get uremia with the disease deteriorating day after day.
The patients whose serum creatinine is more than 445 μmoI/L has suffered uremia.
Apart from nephropathy, serum creatinine can also increase due to the abnormal condition of other tissues and organs. The difference is that: if the renal failure is caused by nephropathy, the serum creatinine is usually more than 200μmoI/L. However, if the decrease of the blood in the kidneys is caused by heart failure, shock, edema, etc, the density of serum creatinine is less than 200μmoI/L. The patients whose serum creatinine is over 442μmoI/L can consider accept dialysis treatment, and those whose serum creatinine is more than 530μmoI/L must accept dialysis . Diabetes can easily be combined with the lesion of heart, blood vessel of brain and neuro , and worsen the disease ,so patients with diabetes and end- stage renal failure must receive dialysis as soon as possible.
As one of renal function detection indexes, creatinine plays an important reminding role. The patients can cooperate better with the doctors, protect themselves by learning diabetic nephropathy and other related content.