Worsening of diabetic nephropathy and high-protein diet. Diabetic nephropathy is the main pathological features of the glomerular basement membrane uniform hypertrophy, increased mesangial matrix cells, mesangial cells were nodular hypertrophy. The causes of diabetic nephropathy is that we must understand, experts introduced us to lead the cause of diabetic nephropathy.
1 Blood Pressure: Diabetic patients due to lipid metabolism disorders, atherosclerosis and many other reasons, a large number of those with hypertension, these patients can be seen almost urine protein, suggesting that renal damage in general.
2 white diet exacerbate the deterioration of diabetic nephropathy; diabetic patients due to strict limits carbohydrate intake, and high protein food supply fiber-based, trade-off, resulting in protein decomposition products and phosphorus loads and excessive accumulation, thereby exacerbating the DN pathological damage.
So, diabetic nephropathy induced reasons, what does?
Diabetic nephropathy is closely related with high blood sugar, poor blood sugar control can accelerate the development of diabetic nephropathy, good blood glucose control can significantly slow down its development. High blood sugar and glycation endproducts increase induced mesangial cell proliferation, extracellular matrix increased mesangial expansion, glomerular basement membrane thickening.
Diabetic nephropathy and genetic factors. Some long-term good glycemic control in patients with diabetic nephropathy also can occur. Glucose transporter proteins on mesangial cells mainly glucose transporter. Recent studies have found that different individuals with diabetes GLUT1 menu mesangial cells and regulation of the differences may be susceptible to kidney damage in some patients one of the factors. And the incidence of diabetic nephropathy also showed family aggregation, family history of hypertension in some patients with diabetes, the incidence of diabetic nephropathy was significantly higher than in patients with no family history of hypertension.
Hypertension and diabetic nephropathy is not directly related, but the course of pre-existing hypertension or microalbuminuria to elevated blood pressure can accelerate the progress of diabetic nephropathy after and deterioration of renal function, increased urinary albumin excretion.
Diabetic nephropathy, renal hemodynamic abnormalities. In patients with diabetic nephropathy, which is a critical factor. Patients with diabetic nephropathy should be noted that, to maintain their bodily functions remain unchanged, the normal state of mind, it can prevent and improve their disease, completely away from diabetic nephropathy torture.
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