The kidneys are important organs of the human body, some of the standard evaluation of kidney function is good or bad, we know that some patients with renal failure appears unusually high creatinine phenomenon, but there is a friend that reflect their own low creatinine found in urine creatinine matter how low This is confusing. Creatinine is an important indicator of kidney disease, creatinine instability especially low, very puzzling, experts say, in fact, the severity of kidney damage with a positive correlation between creatinine values. In fact, creatinine increase was mainly due to kidney damage, leading to creatinine is not out of the body, so that the elevated creatinine.
Originally the toxic creatinine, serum creatinine and urine creatinine is divided into two kinds. Creatinine is a muscle in the human body metabolic product of muscle metabolism can produce per 20g 1mg creatinine. Body produces creatinine excreted primarily by glomerular filtration. If an exception occurs at this stage filtration, it would result in serum creatinine can not be properly discharged residue retention in the body caused by the phenomenon.
Serum creatinine: normal serum creatinine in 88-176μmoI / L. When the blood creatinine higher than the upper limit of normal, serum creatinine was checked out of the high, that is, we often say that the creatinine is high.
Urine creatinine: mainly from blood through glomerular filtration excreted in the urine creatinine, creatinine high, often accompanied by urinary creatinine is low.
After kidney damage, kidney cell inflammation, glomerular filtration function is severely impaired, creatinine can be excreted through the kidneys, which accumulates in the blood, resulting in high serum creatinine, and patients will have high blood pressure, swelling and other symptoms of altitude reaction . So, we can see that the elevated creatinine and closely linked to kidney damage, kidney damage severity with a positive correlation between creatinine values.
Is due to low creatinine in the kidneys by a variety of causes of violations, the first occurrence of impaired renal intrinsic cell phenotype, the formation of pathological changes, stimulate kidney fibroblasts into myofibroblasts, and while violating and inspire the inherent normal kidney tissue, place the same lesions, thus forming the kidneys from the point to the surface, the part to the whole, the process of expansion of the spread of excitation type, to enter the device quality injury period (i.e. period renal function), this constantly due to kidney damage, and its function has decreased excretion of waste and causing creatinine and other toxins in the body aggregation, which appears in blood creatinine, blood urea nitrogen, creatinine in urine decreased renal filtration rate, etc. . While patients will have high blood pressure, high degree of swelling and other symptoms elsewhere in the body.
In addition, the experts pointed out that the human body muscle metabolism creatinine substance is mainly produce creatine, creatinine excretion through the kidneys into the body. Under normal circumstances, the body's muscle mass is relatively stable, the production amount of creatinine is constant, depending on the level of serum creatinine renal excretion of creatinine much. Is worth noting that the compensatory kidney function is very powerful, if both kidneys are normal, as long as one functioning kidney, serum creatinine can be maintained at normal levels. That is, the degree of renal impairment accounted for more than half of the entire kidney, the only cause elevated serum creatinine. Therefore, serum creatinine and does not reflect an early, mild decline in renal function. So found the problem to be solved.
Creatinine excretion of the body of waste, kidney is the main excretory organs, creatinine is likely to be high or low kidney problems. Kidney disease patients in addition to regular treatment, the most important in our daily lives is the prevention and care of patients with kidney disease, only the correct prevention and maintenance in order to alleviate the condition of the kidney patients, early rehabilitation.
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