Uremia occurs, not only kidney patients suffered serious damage kidney function, and in patients with various body systems will appear different syndromes.
Uremic patients may have toxic effects of substances there are about 20 species, according to the relative molecular mass can be divided into small molecules (less than 500), the numerator (500 to 5000) and macromolecules (greater than 5000) categories. Urea itself is very low toxicity, when the body when high concentrations cause symptoms, such as fatigue, headache, nausea, vomiting, bleeding tendency, etc., but urea levels reflect a group of proteins in vivo metabolite accumulation level, and long-term toxicity of urea action with the cyanate decomposition products, which can cause clinical symptoms L described.
The molecules: the molecules may include a high concentration of toxic substances metabolites, increased concentration of normal structure and metabolites produced by many cell metabolism belly, or bacterial cell lysate. In particular, the molecular weight between 13 and 3400 helper substance that is the main component of the body of uremic toxins, in vivo accumulation of uremic increased significantly.
Do not understand the circumstances, hypertension often misdiagnosed as essential hypertension; left heart failure often misdiagnosed as coronary heart disease, hypertensive heart disease; breathing difficulties misdiagnosed as pulmonary heart disease; acid misdiagnosed as chronic respiratory toxicity bronchitis infection and acute; uremic lung misdiagnosed as bronchiectasis, bronchial asthma. High concentrations can cause uremic encephalopathy molecular substances, peripheral neuropathy, insulin activity inhibition, platelet dysfunction, immune dysfunction, erythropoietic disorders, sexual dysfunction and exocrine atrophy.
Insomnia, depression, inability to concentrate misdiagnosed as neurosis; hallucinations, psychosis often misdiagnosed as psychosis; seizures misdiagnosed as epilepsy. Histamine fatty amines, aromatic amines and polyamines: aliphatic amines include methylamine a one, two - methylamine, 3 a methylamine, ethanolamine, etc.: polyamines include spermine, spermidine, putrescine and cadaverine. Macromolecules: The main endocrine hormones, such as growth hormone, parathyroid hormone (PTH), adrenocorticotropic hormone, insulin, glucagon blood sugar hormone, gastrin, renin and so on.
Iliac graft implantation fossa, susceptible to late pregnancy increases the oppression of the uterus, so that further increase the burden of renal physiology. Uremia period, kidney patients may experience nausea, vomiting, hiccups, vomiting blood or blood in the stool, anorexia, diarrhea, etc., when these symptoms appear when the patient may think they have a GI of bad treatment in gastroenterology, some doctors will misdiagnosed patients hepatitis, dysentery, gastritis, peptic ulcer or bleeding, gastroenteritis.
Urine methyl guanidine and guanidine Amber acid concentrations were elevated methyl anus is strongly alkaline compounds are highly toxic, mainly accumulate in the intracellular fluid, can cause nausea, vomiting, diarrhea, anemia, skin itch spasm, reducing the absorption of calcium , stomach ulcer, bleeding, convulsions and consciousness disorders. In vivo accumulation of urea into the digestive tract, bacteria in the intestines by urease to form ammonia, can stimulate the gastrointestinal mucosa caused by fibrinous inflammation, and even the formation of ulcers and bleeding. Wide range of diseases, from the mouth, esophagus until the rectum can be involved. In uremic esophagitis, gastritis and colitis is more common. Patients often have nausea, vomiting, abdominal pain, diarrhea, bloody diarrhea and other symptoms.
Uremia occurs because the body's water and electrolyte kidney patients all the acid-base balance disorders, resulting in a very complex clinical manifestations. Uremia are not familiar with, do not know, maybe it will look in the wrong department uremic patients heal, but delayed the timing of treatment of uremia. The end products of protein metabolism is mainly urea, relative molecular mass of 60, in which nitrogen is 28.
Uremia common gastrointestinal symptoms (such as loss of appetite late, nausea, vomiting, etc.) mainly by gastrointestinal motility dysfunction causes, most of delayed gastric emptying and other motor dysfunction in remission after the start of dialysis, but some patients these symptoms by the uremic lesions caused by autonomic function, dialysis often can not take effect, the reason so uremia caused renal failure occurs gradually, accumulation of toxins caused by Thanh Hoa tract symptoms, dehydration caused by an imbalance in the molecule toxins clear enough.
In uremia concentration of these substances in the body, may have toxic effects: Among current understanding clearest, most important is I bite H, it can lead to multi-system damage, leading to renal osteodystrophy, itchy skin sputum , hyperlipidemia, myocardial damage, anemia and other illnesses. Guanidine derivatives of certain amino acids and creatinine metabolites, uremic patients have muscle substances accumulate when protein intake is increased.
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