The Reason Why Creatinine Is High

Why is creatinine high? Creatinine is an index which can judge the kidney’s function. What is creatinine? Creatinine is a metabolism product which should be discharged out together with urine. Generally, 20g muscles can produce 1 mg creatinine. And it is filtrated out through renal glomeruli. Actually, creatinine can be divided into two kinds. One is from the metabolism of muscles and one is from the food we take in. Generally, the level of creatinine is stable in the body and does not influenced by the food we take in.
The reason why creatinine is high goes as follows:
After invaded by kinds of pathological factors, the renal intrinsic cell will have a phenotype transformation and form pathological damage, which can stimulate the fibroblast to transform into myofibroblastlike cells. In addition, it can invade the intrinsic renal tissues and the same pathological damage takes place as well. At this time, kidney function is damaged and then the filtration function to toxins such as creatinine, blood urea nitrogen, urea acid, and so on. What’s more, other symptoms such as high blood pressure, edema will also appear.
For chronic kidney disease patients, the creatinine and GFR in different stages is as follows:
Stage 1 GFR ≥90 mL/min/1.73m2 creatinine normal
Stage 2 GFR 60-89 mL/min/1.73m2 creatinine 133-177μmol/L (1.6-2.0mg/dL)
Stage 3 GFR 30-59 mL/min/1.73m2 creatinine 186-142μmol/L (2.1-5.0mg/dL)
Stage 4 GFR 15-29 mL/min/1.73m2 creatinine 451-707μmol/L (5.1-7.9mg/dL)
Stage 5 GFR <15 mL/min/1.73m2 creatinine >707μmol/L (>8.0mg/dL)
Since long time high level of creatinine can do harm to the body and cause a series of complications, we should find out and apply effective measures. Chinese Medicine can repair the damaged intrinsic cells such as renal glomerular filtration membrane because there are materials which can improve the insufficiency of blood and oxygen and supply more blood and oxygen. After the renal glomerular filtration membrane is repaired, high creatinine level will turn normal.
However, Chinese Medicine can only treat those with damaged intrinsic cells and can not deal with those necrotic intrinsic cells. It is the necrotic ones that make the kidney shrink, worsening the renal fibrosis. Stem cell transplant can achieve it. Stem cells are initial cells with strong self-renewing and multi-differentiation abilities. They are infused into human body through intravenous injection, and then stem cells will transfer into the kidney lesions by auto-homing function. Stem cells can adjust the immune disorder by change the genes and repair the damaged glomeruli by generating into new renal intrinsic cells to replace the scarred ones.
In addition, the application of Chinese Medicine can also create a clean environment for the transplantation of stem cell. In other words, the combination of Chinese Medicine and stem cell transplantation can give hope and good news to patients with high creatinine because as long as the renal function is recovered, high creatinine will decline consequently.