Why high blood pressure in patients with chronic nephritis

Patients with chronic nephritis dangerous why can appear the phenomenon of high blood pressure?
First of all, the kidney is the main organ metabolism of water and sodium, chronic nephritis make kidney tissue damage and affect the kidney function, water, sodium excretion is disorder, cause water sodium retention. And this phenomenon has led to an increased blood volume, so that the blood pressure.
Again, as a result of kidney ischemia, the change of the renal vascular tension cause renin secretion increased, through the role of the renin - angiotensin, promote aldehyde sterol and vasopressin secretion increased, leading to the distal tubule absorbs water, sodium increases, this kind of situation will lead to increased blood pressure.
So, how to control high blood pressure, chronic nephritis?
Angiotensin converting enzyme inhibitors as first-line antihypertensive drugs.
According to many clinical studies confirmed that calcium antagonists, such as benzene, pyridine, monica nitrate equal treatment of high blood pressure and slow deterioration of renal function have relatively definite curative effect. Research suggests that calcium antagonists despite a slight expansion goal the role of the small arteries, but because it has a significantly lower blood pressure, therefore, can make the intact or only part of the involvement of glomerular high hemodynamic and metabolic conditions improve.
In addition, calcium antagonists reduce oxygen consumption, platelet aggregation, and through the cell membrane effect to reduce calcium ion and reduce the sedimentation of the interstitial cell membrane excessive oxidation, so as to alleviate kidney damage and stable renal function.
Beta blockers, such as metoprolol, ammonia acyl reassuring, has good curative effect of renin dependency high blood pressure. Beta blockers have reduced renin effect, the drug is reduced the cardiac output, but does not affect the renal blood flow and GFR, therefore, also used in the treatment of renal hypertension. It should be noted that some beta blockers, such as ammonia acyl peace and naphthalene hydroxyl reassuring, low fat soluble, renal excretion, renal full-time dose adjustment should be paid attention to more and longer time.
In addition, the expansion of blood vessels drugs such as hydralazine have antihypertensive effect, it can be associated with beta blockers used, reduce the expansion of blood vessels stimulates renin angiotensin system such as side effects, such as the heart beats faster, water sodium retention), and can improve the effect of treatment. Hydralazine generally 200 mg per day, but the sample must be alert to the drug induced lupus erythematosus (sle) syndrome.
For patients with chronic kidney disease with edema, if renal function is good, can use plus thiazide diuretic; Memory of kidney (serum creatinine > 200 mu mol/L), thiazide drugs curative effect is poor or ineffective, should use medullary loop diuretics. Application of diuretics should pay attention to the body electrolyte disorder, and attention should be paid to tend to increase the hyperlipidemia and high coagulation state.
Experts say, if the strict control of blood sugar at the same time, strict control of blood pressure, reduces delay diabetes kidney disease or high blood pressure caused by the occurrence of renal damage, so it is imperative to control high blood pressure in patients with chronic nephritis. Above is relevant experts in our introduction, if you still have what knowledge is not very understanding, can call free hotline, our experts can also leave your contact information, we will contact you as soon as possible.