Chronic nephritis can aggravate coronary heart disease, too?

What is coronary heart disease? Coronary heart disease or coronary heart disease. Due to abnormal lipid metabolism, blood lipid composure on the arterial intima was smooth, the arterial intima some similar atherosclerosis and lipid accumulation and become white patches, known as atherosclerosis. These plaques increases caused arterial lumen, blood is blocked, heart ischemia, produce angina.
Experts say that to a certain stage of the impact on chronic nephritis can be not only the kidney, also may lead to cardiovascular disease. Especially the elderly, chronic nephritis causes human kidney function decline, but also greatly increase the risk of coronary disease, this is more serious than ordinary people.
Then why nephritis can lead to coronary heart disease?
The study found, with 8% of people are now kidney function decline, especially the elderly. In these people, the most common cardiovascular disease, and renal function impairment degree aggravating, the increased incidence of coronary heart disease (CHD). Associated with cardiovascular disease mortality in patients with chronic kidney disease 10 ~ 30 times that of the general population.
In patients with chronic nephritis, traditional coronary heart disease risk factors (such as hypertension, hyperlipidemia, diabetes, smoking, etc.) still has forecast. And high blood pressure of patients with chronic glomerulonephritis may be more serious than the general population, and these patients has increased homocysteine, oxidative stress, lipid metabolism disorders and inflammatory markers, calcium and phosphorus metabolism, reduce vascular remodeling and compliance, promote the formation of atherosclerosis.
Diabetes patients in the process of the development of the disease, there are usually chronic renal impairment. Clinical studies found that the occurrence of microalbuminuria in diabetic patients, often accompanied by lipid metabolism disorders, poor control of blood sugar, high blood pressure, carotid intimal thickening, left ventricular hypertrophy, and various types of coronary heart disease. Many studies have shown that diabetic patients with microalbuminuria myocardial infarction, stroke, and cardiovascular disease mortality and all-cause mortality of diabetic patients with microalbuminuria with no respectively 2 times. Microalbuminuria cause of poor prognosis in diabetic patients may have, the traditional high incidence of coronary heart disease risk factors in these patients, endothelial dysfunction, increased vascular permeability, abnormal blood coagulation fibrinolytic system and inflammation. Microalbuminuria is also often said organ failure.
Chronic kidney disease patients also had higher incidence of cardiomyopathy. High blood pressure and hardening of the arteries that higher pressure load, causes the left ventricle centripetal hypertrophy. In addition, anemia, liquid load and the capacity of the arteriovenous fistula caused by load increasing, lead to left ventricular hypertrophy with expansion. These changes in the structure of the heart, the ventricular systolic function and diastolic dysfunction, clinical manifestations of heart failure, myocardial ischemia. Especially in dialysis patients, due to the water retention of sodium and ultrafiltration effect lead to high blood pressure or low blood pressure, heart failure diagnosis is difficult. Dialysis patients with heart failure is often serious cardiovascular disease, independent risk factors for long-term prognosis.
Clinically, usually according to the determination of serum creatinine and estimated glomerular filtration rate and creatinine clearance, and renal function. Xi 'an tongji kidney disease hospital clinical study found that when the creatinine increased, although coronary artery operation success rate as high as 90% above stenting (pci), but must adopt measures to protect the kidney during interventional treatment, in order to improve its overall effect. These protective measures, fully rehydration (including water and intravenous fluids) is the most important and convenient. At the same time, try to reduce the dosage of contrast agent and choose proper contrast agent, was the key to preventing further development of renal impairment.
Can be seen from the above, we will also aggravate the onset of coronary heart disease, chronic nephritis so be vigilant, do not let the disease hurt their health. Above is the xi 'an tongji hospital expert professional analysis on this problem, if you have any questions can consult our experts online.